Differences in Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropin and Cortisol before and after Weight Loss
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منابع مشابه
Corticotropin-releasing hormone effects on luteinizing hormone and cortisol secretion in intact female rhesus macaques.
It is generally accepted that corticotropin-releasing hormone (CRH) is the central mediator of stress-activated changes in the pituitary-adrenal axis because it results in the release of ACTH and ultimately increases the systemic levels of cortisol. And, because in some situations CRH also inhibits the hypothalamic release of GnRH, it has been presumed that it plays the central role in stress-r...
متن کاملCorticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency.
Corticotropin-releasing hormone (CRH)-deficient (KO) mice provide a unique system to define the role of CRH in regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Despite several manifestations of chronic glucocorticoid insufficiency, basal pituitary proopiomelanocortin (POMC) mRNA, adrenocorticotrophic hormone (ACTH) peptide content within the pituitary, and plasma ACTH concentrations...
متن کاملCorticotropin-releasing hormone physiology
Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
متن کاملCorticotropin-releasing hormone receptors.
Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural...
متن کاملCorrelated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling.
Stress affects the hippocampus, a brain region crucial for memory. In rodents, acute stress may reduce density of dendritic spines, the location of postsynaptic elements of excitatory synapses, and impair long-term potentiation and memory. Steroid stress hormones and neurotransmitters have been implicated in the underlying mechanisms, but the role of corticotropin-releasing hormone (CRH), a hyp...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 1997
ISSN: 0021-972X
DOI: 10.1210/jc.82.6.1874